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HYPIEND

HYPIEND

Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations

Exposure to multiple endocrine disrupting chemicals (EDC) is an environmental insult that interferes with the development and function of the endocrine system, governed by the hypothalamus-pituitary (HP) axis. This interaction is specially concerning in developmental stages of life, such as the perinatal period and puberty. Despite the current body of knowledge on EDC actions on the endocrine system, a comprehensive, holistic understanding of the impact on the HP axis is still lacking. HYPIEND aims to understand the effects of EDC co-exposure in the function and epigenetic programming of the HP axis to delineate interventional strategies for minimizing exposure and consequences on the neuroendocrine system during the perinatal and pre-pubertal stages. To do that, a computational toxicology methodological framework will be built leveraging public data and state of the art data analysis techniques to define EDC co-exposure patterns in target population. The resulting patterns will be evaluated in a sequential tiered approach consisting in cell-based screenings, Danio rerio models of HP axes, in vitro, in silico and in vivo models of placenta and blood brain barrier diffusion and new models of organoids-based organ-on-chip recapitulating the HP axis. EDC effects on epigenetic programming will be evaluated in preclinical models of perinatal and early childhood. Whole genome DNA methylation patterns in the different models will be explored as a source of non-invasive biomarkers of HP axis disruption by EDC. The knowledge generated in preclinical models will be applied in two multi-centre-controlled intervention studies intended to minimize exposure to EDC in children in the perinatal and pre-puberty stages. HYPIEND outcomes will be novel approach methodologies based in in vitro and in silico models, non-invasive biomarkers of HP disruption by EDC and new intervention strategies to minimize EDC exposure in sensitive population.

OUR ROLE

COMMUNICATION,  DISSEMINATION AND EXPLOITATION
ENCO is the leader of the Communication, Dissemination & Exploitation activities in WP5. It will work to (i) monitor and track all dissemination activities and execute the dissemination strategy of HYPIEND; (ii) capture and effectively manage the generated IP and to establish strategies to exploit HYPIEND results; (iii) ground a permanent hub for policy makers, public authorities, EU risk assessment bodies and regulators.

 

WEBSITE URL
https://hypiend.eu/

FUNDING PROGRAMME
HORIZON EUROPE

BUDGET
€ 6.694.438,25

PROJECT DURATION
60 months

START DATE
January 1st, 2024

PROJECT SOCIAL NETWORK:


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